Is there a generic version of Zepbound?

Zepbound is a brand name medication. Generic alternatives may be available — ask your pharmacist or search our drug database for equivalent generics, which typically cost 80-85% less.

Brand Name NDC 00002246080

Zepbound 12.5 Mg/0.5 ML Pen

NADAC pharmacy acquisition cost from CMS

NADAC Per Unit

$526.42

Pharmacy acquisition cost

Est. 30-Day Supply

$15,793

At NADAC cost (1/day)

Est. 90-Day Supply

$47,378

At NADAC cost (1/day)

Est. Retail Price / Unit

$710.67

~35% pharmacy markup

Est. Retail 30-Day

$21,320

Without insurance

Est. Annual Cost

$259,394

Retail, 1 unit/day

About Zepbound

Zepbound is a once-weekly injectable for chronic weight management. It contains tirzepatide (same as Mounjaro) and has demonstrated the highest weight loss of any approved medication in clinical trials (up to 22.5%).

Understanding Drug Pricing

NADAC (shown above) — What the pharmacy pays the wholesaler for this drug. This is the most transparent baseline cost, published weekly by CMS.

Retail Price — Pharmacies add a dispensing fee ($2-$15) and markup (20-50%). This is what you pay without insurance or discount cards.

Insurance Copay — With insurance, you typically pay a flat copay ($5-$15 generic, $25-$50 brand) regardless of the NADAC cost.

Frequently Asked Questions

How much does Zepbound cost?

The pharmacy acquisition cost (NADAC) for Zepbound 12.5 Mg/0.5 ML Pen is $526.42 per unit. A 30-day supply at 1 unit per day costs approximately $15,793.

How much does Zepbound cost without insurance?

Without insurance, expect to pay approximately $21,320 for a 30-day supply. Pharmacy discount programs (GoodRx, RxSaver, Cost Plus Drugs) and manufacturer coupons can reduce this significantly. Ask your doctor if a generic alternative is available — generics typically cost 80-85% less.

Is Zepbound available as a generic?

Zepbound is a brand name medication. Generic alternatives may be available. Ask your pharmacist about equivalent generics which can save 80-85%.