CPT 45390 Surgery - Digestive

How Much Does Colonoscopy with Resection Cost?

Also known as: Colonoscopy w/resection (CPT 45390)

Colonoscopy with removal of large polyp using submucosal injection and snare technique.

The total estimated cost of Colonoscopy with Resection (CPT 45390) is $975 to $1,829, including hospital fees, anesthesia, and supplies. The surgeon's Medicare fee alone is $290.

Total Estimated Cost of Care

$975 — $1,829

This estimate includes hospital facility fees, anesthesia, and supplies .

Surgeon/Physician Fee
$290
Hospital Facility Fee
$871
Anesthesia (est.)
$58
Important: The physician fee of $290 shown in the cost cards below is what Medicare pays the surgeon/doctor only. The hospital charges a separate facility fee that typically makes up 70-85% of the total cost.
Medicare Physician Fee (Facility Setting)
$290
Physician component only — CMS PFS 2026

Patient Guide: Colonoscopy with Resection

What you need to know before your appointment

What to Expect

During colonoscopy, fluid is injected beneath a large polyp to lift it, then a snare wire is used to remove it. This technique allows safe removal of larger polyps.

How Long Does It Take?

30-90 minutes

Common Reasons Doctors Order This

Large colon polyp removal, flat polyp removal, preventing need for surgery

How to Prepare

Same bowel prep as standard colonoscopy. Stop blood thinners as directed. You may need follow-up colonoscopy in 3-6 months.

Procedures Commonly Done Together

These procedures are frequently performed alongside Colonoscopy w/resection

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How to Reduce Your Cost for Colonoscopy w/resection

Practical tips that can save you hundreds or thousands of dollars

  • 1
    Ask about cash-pay discounts

    Many hospitals and clinics offer 20-40% discounts for self-pay patients. Always ask before scheduling.

  • 2
    Compare facility vs. office setting costs

    Some procedures cost significantly less in an office setting than a hospital. Ask your provider about options.

  • 3
    Shop around — costs vary significantly

    Costs can vary 2-3x between providers in the same city. Get quotes from multiple facilities.

How is the Price Calculated?

Medicare calculates procedure payments using Relative Value Units (RVUs). Each procedure has three components multiplied by a conversion factor ($33.40 in 2026) and adjusted by geographic cost indices.

5.89
Work RVU
2.15
Practice Expense RVU
0.65
Malpractice RVU
8.69
Total RVU

Payment = Total RVU (8.69) x CF ($33.40) = $290

Frequently Asked Questions

How much does Colonoscopy w/resection cost?

The Medicare facility rate for Colonoscopy w/resection is $290. Commercial insurance rates typically range from 150% to 250% of Medicare (varies by plan).

How much does Colonoscopy w/resection cost without insurance?

Without insurance, the cost of Colonoscopy w/resection can range from 150% of Medicare to 500% of Medicare depending on the facility. Many hospitals and clinics offer self-pay discounts of 20-40% off their chargemaster price. Always ask about cash pricing before your visit.

Does insurance cover Colonoscopy w/resection?

Most commercial health insurance plans and Medicare cover Colonoscopy w/resection when ordered by a physician for a medically necessary reason. Your out-of-pocket cost depends on your plan's deductible, copay/coinsurance structure, and whether you use an in-network provider. Check with your insurance company before scheduling to confirm coverage and get a cost estimate.

Why does the cost vary so much by location?

Medicare adjusts payments using Geographic Practice Cost Indices (GPCIs) that reflect local differences in physician work costs, practice expenses, and malpractice insurance. Manhattan, San Francisco, and other high-cost areas pay significantly more than rural regions. Commercial insurers follow similar geographic patterns.

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