How Much Does Diagnostic Bone Marrow Biopsies Cost?
Also known as: Dx bone marrow biopsies (CPT 38221)
The total estimated cost of Diagnostic Bone Marrow Biopsies (CPT 38221) is $194 to $365, including hospital fees, anesthesia, and supplies. The surgeon's Medicare fee alone is $58.
Total Estimated Cost of Care
This estimate includes hospital facility fees, anesthesia, and supplies .
Procedures Commonly Done Together
These procedures are frequently performed alongside Dx bone marrow biopsies
How to Reduce Your Cost for Dx bone marrow biopsies
Practical tips that can save you hundreds or thousands of dollars
- 1 Ask about cash-pay discounts
Many hospitals and clinics offer 20-40% discounts for self-pay patients. Always ask before scheduling.
- 2 Compare facility vs. office setting costs
For this procedure, the office rate ($167) differs from the facility rate ($58). Ask if it can be done in an office setting.
- 3 Shop around — costs vary significantly
Costs can vary 2-3x between providers in the same city. Get quotes from multiple facilities.
How is the Price Calculated?
Medicare calculates procedure payments using Relative Value Units (RVUs). Each procedure has three components multiplied by a conversion factor ($33.40 in 2026) and adjusted by geographic cost indices.
Payment = Total RVU (5.00) x CF ($33.40) = $167
Related Procedures
Similar procedures in the same category or body system
Frequently Asked Questions
How much does Dx bone marrow biopsies cost?
The Medicare facility rate for Dx bone marrow biopsies is $58. Commercial insurance rates typically range from 150% to 250% of Medicare (varies by plan).
How much does Dx bone marrow biopsies cost without insurance?
Without insurance, the cost of Dx bone marrow biopsies can range from 150% of Medicare to 500% of Medicare depending on the facility. Many hospitals and clinics offer self-pay discounts of 20-40% off their chargemaster price. Always ask about cash pricing before your visit.
Does insurance cover Dx bone marrow biopsies?
Most commercial health insurance plans and Medicare cover Dx bone marrow biopsies when ordered by a physician for a medically necessary reason. Your out-of-pocket cost depends on your plan's deductible, copay/coinsurance structure, and whether you use an in-network provider. Check with your insurance company before scheduling to confirm coverage and get a cost estimate.
Why does the cost vary so much by location?
Medicare adjusts payments using Geographic Practice Cost Indices (GPCIs) that reflect local differences in physician work costs, practice expenses, and malpractice insurance. Manhattan, San Francisco, and other high-cost areas pay significantly more than rural regions. Commercial insurers follow similar geographic patterns.